Regulation of the endothelial plasminogen activator system by fluvastatin

Regulation of the endothelial plasminogen activator system by fluvastatin. Role of Rho family proteins, actin polymerisation and p38 MAP kinase.

Statins are cholesterol-lowering drugs that exert pleiotropic effects which include changes in the plasminogen activation (PA) system of endothelial cells (EC). It was the objective of this study to investigate the signal transduction pathways by which statins increase the expression of tissue-type PA (t-PA) and decrease PA inhibitor type 1 (PAI-1) in human umbilical vein EC. Fluvastatin treatm...

Transcriptional and posttranscriptional regulation of the plasminogen activator system.

The core protein components of the plasminogen activator (PA) system are two plasminogen activators, two plasminogen activator inhibitors and a urokinase type plasminogen activator-specific cell surface receptor. Various types of biological regulation are exerted through the interplay of these components mutually and with extracellular matrix proteins and cell membrane proteins, with or without...

expression of the recombinant plasminogen activator (reteplase) by a non-lytic insect cell expression system

reteplase is a potent thrombolytic agent which is widely used in the management of acute myocardial infarction and stroke. it belongs to the third generation of the thrombolytic drugs and has been derived from native human tissue plasminogen activator by removing three domains of it and keeping the kringle 2 and serine protease domains. however, the high cost of this drug, has limited the appli...

The plasminogen activator/plasmin system.

The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1.

Nicotine, a primary component of tobacco, is one of the most abused drugs worldwide. Approximately four million people die each year because of diseases associated with tobacco smoking. Mesolimbic dopaminergic neurons mediate the rewarding effects of abused drugs, including nicotine. Here we show that the tissue plasminogen activator (tPA)-plasmin system regulates nicotine-induced reward and do...